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20262025202420232022Full bibliography

2026

  • Stratton H, Dolatyarieslami M, Moutal A, Patwardhan A, Rowbotham M, Navratilova E, Porreca F. Can new understanding of sexually dimorphic pain mechanisms provide a path to improved postoperative pain outcomes in women? Pain. 2026 Mar 25. doi: 10.1097/j.pain.0000000000003966. Epub ahead of print. PMID: 41875281.
  • Salih LY, Dumaire NLA, Gieré C, Vest E, Alkhateeb H, Moritz CP, Tholance Y, Camdessanché JP, Antoine JC, Honnorat J, Kafaie J, François-Moutal L, Moutal A. Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy. Adv Sci (Weinh). 2026 Feb 17:e11413. doi: 10.1002/advs.202511413. Epub ahead of print. PMID: 41700748.
  • Handlin LJ, Gieré C, Dumaire NLA, Salih L, Moutal A, Dai G. Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons. J Gen Physiol. 2026 May 4;158(3):e202513925. doi: 10.1085/jgp.202513925. Epub 2026 Mar 12. PMID: 41818135; PMCID: PMC12981344. 
  • Desprez F, Remize S, François-Moutal L, Ung DC, Dangoumau A, Marouillat S, Kennedy J, Low KJ, Kumps C, Unger S, Keren B, de Sainte Agathe JM, Poirsier C, Mirzaa GM, Aldinger KA, Lesca G, Ruault V, Finnila CR, Kelley WV, Latner DR, Guptha SN, Tuttle A, Glass I, Chung WK, Hayek JC, Boute O, Moutal A*, Jeanne M*, Laumonnier F*. Missense variants in DPYSL5 associated with neurodevelopmental disorders and brain malformations cause impaired neuronal maturation in vitro. Mol Psychiatry. 2026 Apr;31(4):2178-2190. doi: 10.1038/s41380-025-03364-8. Epub 2025 Nov 24. PMID: 41286434; PMCID: PMC12999515. *co-last authors

2025

  • Martin L, Stratton HJ, Salih LY, Dumaire N, Gomez K, Do LD, Loya-Lopez S, Tang C, Calderon-Rivera A, Ran D, Nunna V, Bellampalli SS, François-Moutal L, Luo S, Porreca F, Ibrahim M, Rogemond V, Honnorat J, Khanna R*, Moutal A*. Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats. Nat Commun. 2025 Aug 7;16(1):7311. doi: 10.1038/s41467-025-62380-y. PMID: 40775229; PMCID: PMC12332130. *co-last authors
  • Stratton HJ, Dolatyari M, Kopruszinski C, Ghetti A, Maciuba S, Bowden G, Rivière P, Barber K, Dodick DW, Edorh E, Dumaire N, Moutal A, Navratilova E, Porreca F. A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain. Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2501229122. doi: 10.1073/pnas.2501229122. Epub 2025 May 12. PMID: 40354542; PMCID: PMC12107140. 
  • Palomino SM, Gabriel KA, Mwirigi JM, Cervantes A, Horton P, Funk G, Moutal A, Martin LF, Khanna R, Price TJ, Patwardhan A. Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9. Sci Rep. 2025 Apr 1;15(1):11116. doi: 10.1038/s41598-025-91153-2. PMID: 40169710; PMCID: PMC11961745. 
  • Martin LF, Almuslim M, Ismail KA, Ibrahim MM, Moutal A, Cheng K, Stratton HJ, Price TJ, Vanderah TW, Olivera BM, Khanna R, Patwardhan A. The conotoxin Contulakin-G reverses hypersensitivity observed in rodent models of cancer-induced bone pain without inducing tolerance or motor disturbance. Pain. 2025 Feb 1;166(2):376-387. doi: 10.1097/j.pain.0000000000003391. Epub 2024 Sep 19. PMID: 39297754; PMCID: PMC11723812.  

2024

  • Lillo Vizin RC, Ito H, Kopruszinski CM, Ikegami M, Ikegami D, Yue X, Navratilova E, Moutal A, Cowen SL, Porreca F. Cortical kappa opioid receptors integrate negative affect and sleep disturbance. Transl Psychiatry. 2024 Oct 4;14(1):417. doi: 10.1038/s41398-024-03123-3. PMID: 39366962; PMCID: PMC11452529.
  • Handlin LJ, Macchi NL, Dumaire NLA, Salih L, Lessie EN, McCommis KS, Moutal A, Dai G. Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons. Nat Commun. 2024 Nov 15;15(1):9898. doi: 10.1038/s41467-024-54053-z. PMID: 39548079; PMCID: PMC11568329.
  • Kopruszinski CM, Lee G, Martin LK, Barber KR, Moutal A, Dodick DW, Navratilova E, Porreca F. A male-specific mechanism of meningeal nociceptor sensitization promoting migraine headache. Cephalalgia. 2024 Sep;44(9):3331024241281493. doi: 10.1177/03331024241281493. PMID: 39233656; PMCID: PMC12204761.
  • Stratton H, Lee G, Dolatyari M, Ghetti A, Cotta T, Mitchell S, Yue X, Ibrahim M, Dumaire N, Salih L, Moutal A, François-Moutal L, Martin L, Navratilova E, Porreca F. Nociceptors are functionally male or female: from mouse to monkey to man. Brain. 2024 Dec 3;147(12):4280-4291. doi: 10.1093/brain/awae179. PMID: 38829801; PMCID: PMC11629683.

2023

  • Gomez K, Santiago U, Nelson TS, Allen HN, Calderon-Rivera A, Hestehave S, Rodríguez Palma EJ, Zhou Y, Duran P, Loya-Lopez S, Zhu E, Kumar U, Shields R, Koseli E, McKiver B, Giuvelis D, Zuo W, Inyang KE, Dorame A, Chefdeville A, Ran D, Perez-Miller S, Lu Y, Liu X, Handoko, Arora PS, Patek M, Moutal A, Khanna M, Hu H, Laumet G, King T, Wang J, Damaj MI, Korczeniewska OA, Camacho CJ, Khanna R. A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2305215120. doi: 10.1073/pnas.2305215120. Epub 2023 Nov 16. PMID: 37972067; PMCID: PMC10666126. 
  • Gomez K, Allen HN, Duran P, Loya-Lopez S, Calderon-Rivera A, Moutal A, Tang C, Nelson TS, Perez-Miller S, Khanna R. Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain. Pain. 2024 Apr 1;165(4):866-883. doi: 10.1097/j.pain.0000000000003080. Epub 2023 Oct 20. PMID: 37862053; PMCID: PMC11389604. 
  • Gomez K, Stratton HJ, Duran P, Loya S, Tang C, Calderon-Rivera A, François-Moutal L, Khanna M, Madura CL, Luo S, McKiver B, Choi E, Ran D, Boinon L, Perez-Miller S, Damaj MI, Moutal A*, Khanna R*. Identification and targeting of a unique NaV1.7 domain driving chronic pain. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2217800120. doi: 10.1073/pnas.2217800120. Epub 2023 Jul 27. PMID: 37498871; PMCID: PMC10410761. *co-last authors
  • Gomez K, Duran P, Tonello R, Allen HN, Boinon L, Calderon-Rivera A, Loya-López S, Nelson TS, Ran D, Moutal A, Bunnett NW, Khanna R. Neuropilin-1 is essential for vascular endothelial growth factor A-mediated increase of sensory neuron activity and development of pain-like behaviors. Pain. 2023 Dec 1;164(12):2696-2710. doi: 10.1097/j.pain.0000000000002970. Epub 2023 Jun 27. PMID: 37366599; PMCID: PMC10751385. 
  • Wu XQ, Tan B, Du Y, Yang L, Hu TT, Ding YL, Qiu XY, Moutal A, Khanna R, Yu J, Chen Z. Glutamatergic and GABAergic neurons in the vLGN mediate the nociceptive effects of green and red light on neuropathic pain. Neurobiol Dis. 2023 Jul;183:106164. doi: 10.1016/j.nbd.2023.106164. Epub 2023 May 20. PMID: 37217103. 
  • Stratton HJ, Boinon L, Gomez K, Martin L, Duran P, Ran D, Zhou Y, Luo S, Perez-Miller S, Patek M, Ibrahim MM, Patwardhan A, Moutal A, Khanna R. Targeting the vascular endothelial growth factor A/neuropilin 1 axis for relief of neuropathic pain. Pain. 2023 Jul 1;164(7):1473-1488. doi: 10.1097/j.pain.0000000000002850. Epub 2022 Dec 19. PMID: 36729125; PMCID: PMC10277229. 
  • Kopruszinski CM, Watanabe M, Martinez AL, de Souza LHM, Dodick DW, Moutal A, Neugebauer V, Porreca F, Navratilova E. Kappa opioid receptor agonists produce sexually dimorphic and prolactin-dependent hyperalgesic priming. Pain. 2023 Jun 1;164(6):e263-e273. doi: 10.1097/j.pain.0000000000002835. Epub 2022 Nov 29. PMID: 36625833; PMCID: PMC10285741.  
  • Duran P, Loya-López S, Ran D, Tang C, Calderon-Rivera A, Gomez K, Stratton HJ, Huang S, Xu YM, Wijeratne EMK, Perez-Miller S, Shan Z, Cai S, Gabrielsen AT, Dorame A, Masterson KA, Alsbiei O, Madura CL, Luo G, Moutal A, Streicher J, Zamponi GW, Gunatilaka AAL, Khanna R. The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels. Br J Pharmacol. 2023 May;180(9):1267-1285. doi: 10.1111/bph.15974. Epub 2023 Jan 15. PMID: 36245395. 
  • Ito H, Navratilova E, Vagnerova B, Watanabe M, Kopruszinski C, Moreira de Souza LH, Yue X, Ikegami D, Moutal A, Patwardhan A, Khanna R, Yamazaki M, Guerrero M, Rosen H, Roberts E, Neugebauer V, Dodick DW, Porreca F. Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance. Brain. 2023 Mar 1;146(3):1186-1199. doi: 10.1093/brain/awac153. PMID: 35485490; PMCID: PMC10169443.

2022

  • Jiang YP, Wang S, Lai WD, Wu XQ, Jin Y, Xu ZH, Moutal A, Khanna R, Park KD, Shan ZM, Wen CP, Yu J. Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement. Arthritis Res Ther. 2022 Dec 23;24(1):277. doi: 10.1186/s13075-022-02975-8. PMID: 36564853; PMCID: PMC9783725. 
  • Loya-López SI, Duran P, Ran D, Calderon-Rivera A, Gomez K, Moutal A, Khanna R. Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons. Neurobiol Pain. 2022 Nov 12;12:100109. doi: 10.1016/j.ynpai.2022.100109. PMID: 36531612; PMCID: PMC9755031. 
  • Xu Z, Wang Y, Moutal A. Editorial: Complementary/Alternative Therapies for Epilepsy and Related Psychiatric Comorbidities. Front Neurosci. 2022 Jun 9;16:947644. doi: 10.3389/fnins.2022.947644. PMID: 35757557; PMCID: PMC9218802. 
  • Gomez K, Tang C, Tan B, Perez-Miller S, Ran D, Loya S, Calderon-Rivera A, Stratton HJ, Duran P, Masterson KA, Gabrielsen AT, Alsbiei O, Dorame A, Serafini M, Moutal A, Wang J, Khanna R. Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca2+ Channels and Pain. ACS Chem Neurosci. 2022 Jul 6;13(13):2035-2047. doi: 10.1021/acschemneuro.2c00256. Epub 2022 Jun 7. PMID: 35671441. 
  • François-Moutal L, Scott DD, Ambrose AJ, Zerio CJ, Rodriguez-Sanchez M, Dissanayake K, May DG, Carlson JM, Barbieri E, Moutal A, Roux KJ, Shorter J, Khanna R, Barmada SJ, McGurk L, Khanna M. Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology. Sci Rep. 2022 May 17;12(1):8140. doi: 10.1038/s41598-022-12191-8. PMID: 35581326; PMCID: PMC9114370. 
  • Watanabe M, Kopruszinski CM, Moutal A, Ikegami D, Khanna R, Chen Y, Ross S, Mackenzie K, Stratton J, Dodick DW, Navratilova E, Porreca F. Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine. Brain. 2022 Aug 27;145(8):2894-2909. doi: 10.1093/brain/awac104. PMID: 35325034; PMCID: PMC9890468. 
  • Martin L, Ibrahim M, Gomez K, Yu J, Cai S, Chew LA, Bellampalli SS, Moutal A, Largent-Milnes T, Porreca F, Khanna R, Olivera BM, Patwardhan A. Conotoxin contulakin-G engages a neurotensin receptor 2/R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception. Pain. 2022 Sep 1;163(9):1751-1762. doi: 10.1097/j.pain.0000000000002561. Epub 2021 Dec 15. PMID: 35050960; PMCID: PMC9198109. 
  • Boinon L, Yu J, Madura CL, Chefdeville A, Feinstein DL, Moutal A*, Khanna R*. Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain. Pain. 2022 Feb 1;163(2):e368-e381. doi: 10.1097/j.pain.0000000000002344. PMID: 35029600; PMCID: PMC8760468. *co-last authors
  • Rivas CM, Schiff HV, Moutal A, Khanna R, Kiela PR, Dussor G, Price TJ, Vagner J, DeFea KA, Boitano S. Alternaria alternata-induced airway epithelial signaling and inflammatory responses via protease-activated receptor-2 expression. Biochem Biophys Res Commun. 2022 Feb 5;591:13-19. doi: 10.1016/j.bbrc.2021.12.090. Epub 2021 Dec 29. PMID: 34990903; PMCID: PMC8792334. 
  • Ikegami D, Navratilova E, Yue X, Moutal A, Kopruszinski CM, Khanna R, Patwardhan A, Dodick DW, Porreca F. A prolactin-dependent sexually dimorphic mechanism of migraine chronification. Cephalalgia. 2022 Mar;42(3):197-208. doi: 10.1177/03331024211039813. Epub 2021 Sep 12. PMID: 34510920; PMCID: PMC11668309.

Full bibliography

 https://pubmed.ncbi.nlm.nih.gov/?sort=date&term=Moutal+A&cauthor_id=41875281